| 別品名 |
Polyubiquitin B antibody, RPS27A antibody, UBA52 antibody, UBB antibody, UBC antibody, ubiquitin B antibody
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| 種由来 |
Bovine
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| 交差種 |
Human
Mouse
Rat
Bovine
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| 適用 |
Western Blot
Enzyme Linked Immunosorbent Assay
Immunohistochemistry
Immuno Fluorescence
Immunocytochemistry (cell)
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| 免疫動物 |
Mouse
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| クローン |
5B9-B3
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| 抗体クラス |
IgG2aκ
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| 標識物 |
Biotin
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| 精製度 |
Ig fraction - Protein G
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| GENE ID |
281370
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| Accession No.(Gene/Protein) |
NP_776558.1, P0CG53
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| 分子量 |
10kDa
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| 概要 |
Mouse monoclonal to Ubiquitin (Biotin). Ubiquitin is a small protein that occurs in all eukaryotic cells. The ubiquitin protein itself consists of 76 amino acids and has a molecular mass of about 8. 5kDa. Key features include its C-terminal tail and the 7 Lys residues. It is highly conserved among eukaryotic species: Human and yeast ubiquitin share 96% sequence identity. The main function of Ubiquitin is to clear abnormal, foreign and improperly folded proteins by targeting them for degradation by the 26S proteosome. Ubiquitination represents an essential cellular process affected by a multi-enzyme cascade involving classes of enzymes known as ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s or Ubcs) and ubiquitin-protein ligases (E3s). Ubiquitin is activated in a two-step reaction by an E1 ubiquitin-activating enzyme in a process requiring ATP as an energy source. The initial step involves production of an ubiquitin-adenylate intermediate. The second step transfers ubiquitin to the E1 active site cysteine residue, with release of AMP. This step results in a thioester linkage between the C-terminal carboxyl group of ubiquitin and the E1 cysteine sulfhydryl group. The third step is a transfer of ubiquitin from E1 to the active site cysteine of a ubiquitin-conjugating enzyme E2 via a trans(thio)esterification reaction. And the final step of the ubiquitylation cascade creates an isopeptide bond between a lysine of the target protein and the C-terminal glycine of ubiquitin. In general, this step requires the activity of one of the hundreds of E3 ubiquitin-protein ligases (often termed simply ubiquitin ligase). E3 enzymes function as the substrate recognition modules of the system and are capable of interaction with both E2 and substrate. Ubiquitination also participates in the internalization and degradation of plasma membrane proteins such as some of the TCR subunits while still ER-membrane associated. Ubiquitin also plays a role in regulating signal transduction cascades through the elimination inhibitory proteins, such as IkappaBalpha and p27...
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| [注意事項] |
納品物の品番末尾にアンダーバーと数字(例：_2)が付与されていることがございますが、これはメーカー側での管理番号となっており、商品の品番とは無関係です。
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| メーカー |
品番 |
包装 |
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BRT
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ORB147500
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200 UG
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※表示価格について
| 当社在庫 |
なし
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| 納期目安 |
約1ヶ月
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| 保存温度 |
-２０℃
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