| 種由来 |
Mouse
|
| 精製度 |
Affinity Purified
|
| 適用 |
Western Blot
Immunohistochemistry
|
| 免疫動物 |
Mouse
|
| 抗体クラス |
IgG1
|
| クローン |
12H6D12
|
| 交差種 |
Human
Mouse
|
| Accession No.(Gene/Protein) |
NM_001199640, O95760
|
| Gene Symbol |
IL33
|
| 使用目的 |
IL-33 Monoclonal Antibody: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1αβ, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-κB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.
|
| その他 |
[locus ID]90865
|
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※サムネイル画像をクリックすると拡大画像が表示されます。
Western blot analysis of IL-33 using 125ng of recombinant IL-33 with IL-33 antibody at 1 ug/mL.
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Western blot analysis of IL-33 using 125ng of recombinant IL-33 with IL-33 antibody at 1 ug/mL.
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| メーカー |
品番 |
包装 |
|
ORG
|
TA320070
|
100 UG
[1ug/ul]
|
※表示価格について
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