種由来 |
Human
|
精製度 |
Affinity Purified
|
適用 |
Western Blot Immuno Fluorescence
|
免疫動物 |
Rabbit
|
抗体クラス |
IgG
|
交差種 |
Human
|
Accession No.(Gene/Protein) |
NM_015020, Q6ZVD8
|
Gene Symbol |
PHLPP2
|
分子量 |
156 kDa
|
使用目的 |
PHLPP2 Antibody: PHLPP2 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. PHLPP2 associates with and is inhibited by adenylyl cyclase type 6 (AC6), thereby allowing Akt activation.
|
その他 |
[locus ID]23035
|
※サムネイル画像をクリックすると拡大画像が表示されます。
Western blot analysis of PHLPP2 in SW480 cell lysate with PHLPP2 antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide.
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Western blot analysis of PHLPP2 in SW480 cell lysate with PHLPP2 antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide.
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|
メーカー |
品番 |
包装 |
ORG
|
TA319840
|
100 UG [1mg/ml]
|
※表示価格について
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