種由来 |
Human
|
精製度 |
Affinity Purified
|
適用 |
Western Blot Immuno Fluorescence
|
免疫動物 |
Rabbit
|
抗体クラス |
IgG
|
交差種 |
Human
|
Accession No.(Gene/Protein) |
NM_003583, Q92630
|
Gene Symbol |
DYRK2
|
使用目的 |
DYRK2 Antibody: DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.
|
その他 |
[locus ID]8445
|
※サムネイル画像をクリックすると拡大画像が表示されます。
Western blot analysis of DYRK2 in 293 cell lysate with DYRK2 antibody at (A) 1 and (B) 2 ug/mL.
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Western blot analysis of DYRK2 in 293 cell lysate with DYRK2 antibody at (A) 1 and (B) 2 ug/mL.
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メーカー |
品番 |
包装 |
ORG
|
TA319749
|
100 UG [1ug/ul]
|
※表示価格について
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