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The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human ASNA1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Lane 1.: HeLa cell lysate
Lane 2.: 293T cell lysate
Lane 3.: MCF7 cell lysate
ICC/IF analysis of ASNA1 in HeLa cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human ASNA1 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
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The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human ASNA1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Lane 1.: HeLa cell lysate
Lane 2.: 293T cell lysate
Lane 3.: MCF7 cell lysate
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| 別品名 |
ATPase ASNA1, ARSA-I, ARSA1, ASNA-I, GET3, hASNA-I, TRC40
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| 種由来 |
Human
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| 交差種 |
Human
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| 適用 |
Western Blot
Enzyme Linked Immunosorbent Assay
Immuno Fluorescence
Immunocytochemistry (cell)
Flow Cytometry
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| 免疫動物 |
Mouse
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| クローン |
AT2A1
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| 抗体クラス |
IgG2bκ
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| 抗原部位 |
a.a.1-348
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| 標識物 |
Unlabeled
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| 精製度 |
Ig fraction - Protein A
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| Accession No.(Gene/Protein) |
NP_004308, O43681
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| 概要 |
ASNA1, also as known as ARSA and TRC40, is the human homolog of the bacterial arsA, a member of the ATPase superfamily. ArsA and ArsB have been postulated to form a membrane complex which functions as an anion-translocating. It recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ArsA hydrolyses ATP in the presence of its anionic substrate antimonite and produces resistance to arsenite and antimonite. The active form of ArsA is a homodimer with four nucleotide binding sites, two from each monomer.
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| 参考文献 |
Ota T and Suzuki Y. (2004) Nat genet 36(1): 40-5
Kurdi-Haidar B.. (1996) Genomics 36(3): 486-91
Stefanovic S. (2007) Cell 128(6): 1147-59
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| メーカー |
品番 |
包装 |
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ATG
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ATGA0293
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50 UL
[1mg/ml]
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※表示価格について
| 当社在庫 |
なし
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| 納期目安 |
1週間程度
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| 保存温度 |
-７０℃
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