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| 分子量 |
3331.81
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| 構造 |
C159H263ClN15O39PS8
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| 概要 |
ATX-Red AR-2 is an in vivo imaging probe for visualizing and measuring ATX activity. It is an analog of the autotaxin substrate lysophosphatidylcholine (LPC) and contains a near-infrared fluor (Licor IRDyeAR 800CW) and quencher (Licor IRDyeAR QC-1). The design is modeled after FS-3 a fluorogenic ATX substrate that is predictive of ATX activity. In the parent compound fluorescence is quenched through intramolecular energy transfer but when autotaxin cleaves ATX-Red AR-2 fluorescence increases. This activation mechanism is specific to autotaxin in vitro and in vivo.Autotaxin which has lysophospholipase D (lysoPLD) activity cleaves choline from lysophosphatidylcholine forming lysophosphatidic acid (LPA) a potent mitogen that as been implicated in the pathophysiology of ovarian cancer. LysoPLD/ATX has been demonstrated to increase cell motility neovascularization proliferation and aggressiveness of tumors and is upregulated in numerous cancer lineages (non-small cell lung glioma mammary carcinoma renal cell carcinoma hepatocellular carcinoma). In addition dysregulation of the ATX/LPA pathway is central to the pathophysiology of idiopathic pulmonary fibrosis rheumatoid arthritis and other inflammatory diseases. Modulation of ATX activity through small-molecules is a currently underexplored target but one with high potential for novel cancer and anti-inflammatory therapeutics.Notice to Purchaser: Echelon Biosciences products are sold for research and development purposes only and are not to be incorporated into products for resale without written permission from Echelon Biosciences. The compound AR-2 and its use in assaying for Lysophospholipase D activity are covered by Echelon Biosciences Inc. US patents 7 485 259 & 7 989 663. The purchase of this product includes a limited non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser's own internal research. For inquiries email busdev@echelon-inc.comThis product is sold for research use only. Not for use in diagnostic therapeutic or in human in-vivo applications. Not for commercial use. Other uses require a license from LI-COR Biotech LLC. Under patents pending. See Technical Data Sheet for more informationBulk discounts available please email echelon@echelon-inc.com for information.
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| メーカー |
品番 |
包装 |
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ECL
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L-2010
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100 UG
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※表示価格について
| 当社在庫 |
なし
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| 納期目安 |
1週間程度
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| 保存温度 |
-２０℃
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