|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
| 分子量 |
3331.81
|
| 構造 |
C159H263ClN15O39PS8
|
| 概要 |
ATX-Red AR-2 is an in vivo imaging probe for visualizing and measuring ATX activity. It is an analog of the autotaxin substrate lysophosphatidylcholine (LPC) and contains a near-infrared fluor (Licor IRDyeAR 800CW) and quencher (Licor IRDyeAR QC-1). The design is modeled after FS-3 a fluorogenic ATX substrate that is predictive of ATX activity. In the parent compound fluorescence is quenched through intramolecular energy transfer but when autotaxin cleaves ATX-Red AR-2 fluorescence increases. This activation mechanism is specific to autotaxin in vitro and in vivo.Autotaxin which has lysophospholipase D (lysoPLD) activity cleaves choline from lysophosphatidylcholine forming lysophosphatidic acid (LPA) a potent mitogen that as been implicated in the pathophysiology of ovarian cancer. LysoPLD/ATX has been demonstrated to increase cell motility neovascularization proliferation and aggressiveness of tumors and is upregulated in numerous cancer lineages (non-small cell lung glioma mammary carcinoma renal cell carcinoma hepatocellular carcinoma). In addition dysregulation of the ATX/LPA pathway is central to the pathophysiology of idiopathic pulmonary fibrosis rheumatoid arthritis and other inflammatory diseases. Modulation of ATX activity through small-molecules is a currently underexplored target but one with high potential for novel cancer and anti-inflammatory therapeutics.Notice to Purchaser: Echelon Biosciences products are sold for research and development purposes only and are not to be incorporated into products for resale without written permission from Echelon Biosciences. The compound AR-2 and its use in assaying for Lysophospholipase D activity are covered by Echelon Biosciences Inc. US patents 7 485 259 & 7 989 663. The purchase of this product includes a limited non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser's own internal research. For inquiries email busdev@echelon-inc.comThis product is sold for research use only. Not for use in diagnostic therapeutic or in human in-vivo applications. Not for commercial use. Other uses require a license from LI-COR Biotech LLC. Under patents pending. See Technical Data Sheet for more informationBulk discounts available please email echelon@echelon-inc.com for information.
|
|
| メーカー |
品番 |
包装 |
|
ECL
|
L-2010
|
10 UG
|
※表示価格について
| 当社在庫 |
なし
|
| 納期目安 |
1週間程度
|
| 保存温度 |
-２０℃
|
|
※当社では商品情報の適切な管理に努めておりますが、表示される法規制情報は最新でない可能性があります。
また法規制情報の表示が無いものは、必ずしも法規制に非該当であることを示すものではありません。
商品のお届け前に最新の製品法規制情報をお求めの際はこちらへお問い合わせください。
|
※当社取り扱いの試薬・機器製品および受託サービス・創薬支援サービス（納品物、解析データ等）は、研究用としてのみ販売しております。
人や動物の医療用・臨床診断用・食品用としては、使用しないように、十分ご注意ください。
法規制欄に体外診断用医薬品と記載のものは除きます。
|
|
※リンク先での文献等のダウンロードに際しましては、掲載元の規約遵守をお願いします。
|
