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| 概要 |
The Autotaxin Sandwich ELISA is a quantitative immunoassay designed for in vitro measurement of ATX levels in cell culture supernatant or human and mouse biological fluids.Sample Volume: 5 AμLSample Number: 40 samples (in duplicate) / 96-well assaySample Type:A？ cell culture supernatant sera plasma urine and ovarian ascitesSpecies of Sample: mouse human ATXProduct BackgroundThe ATX Sandwich ELISA provides a robust and simple method for researchers to measure ATX in biological samples. The concentration of ATX in the sample is determined using a standard curve of known amounts of ATX.Autotaxin also known as ATX ENPP2 lysophospholipase D (lysoPLD) phosphodiesterase 1I± and plasma cell glycoprotein-1 is a secreted glycoprotein that is widely expressed with high levels in the serum. Via its lysoPLD activity autotaxin hydrolyzes lysophosphatidylcholine (LPC) to generate the phospholipid growth factor lysophosphatidic acid (LPA). The enzymea？？s same activity hydrolyzes sphingosylphosphorylcholine (SPC) to form sphinosine-1-phosphate (S1P).Autotaxin was first isolated as the autocrine motility factor secreted from melanoma cells. At that time the enzymea？？s lysoPLD activity had not been identified so it was classified by homology to the ecto-nucleotide pyrophosphatase/phosphodiesterase (NPP) family of enzymes whose members hydrolyze phosphodiester bonds in various nucleotides and nucleotide derivatives. It was initially unclear how nucleotide hydrolysis could lead to the stimulation of cell motility. This mystery was solved when autotaxin was discovered to be identical to serum lysoPLD. Since then the cancer-related activities of autotaxin at least in cultured cells have been attributed to the enzymea？？s lysoPLD activity. In addition to cancer autotaxin has been implicated in a number of diseases including obesity arthritis multiple sclerosis Alzheimera？？s disease and neuropathic pain.Product Keywords: Autotaxin ATX LPA LPC lysophospholipase D Powered by Bioz See more details on Bioz
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| メーカー |
品番 |
包装 |
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ECL
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K-5600
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1 KIT
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※表示価格について
| 当社在庫 |
なし
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| 納期目安 |
1週間程度
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| 法規制 |
安・カルタヘナ
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| 保存温度 |
-２０℃
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