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Nε-カルボキシメチルリジン（CML）の構造
AGE 形成パスウェイ
：CML = N-epsilon-(carboxymethyl)lysine. GOLD = glyoxal-derived lysine dimer. CEL = N-epsilon-(1-carboxyethyl)lysine. MOLD = methylglyoxal-derived lysine dimer. DOLD = 3-deoxyglucosone-derived lysine dimer. 3-DG = 3-deoxyglucosone.
CML-BSA 競合 ELISA のスタンダードカーブ
ヒト血漿中のCML タンパク質付加体
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Nε-カルボキシメチルリジン（CML）の構造
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| 検出系 |
発色
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| 概要 |
Advanced glycation end products (AGE) are formed during the Maillard reaction where reducing carbohydrates react with lysine side chains and N-terminal amino groups of various macromolecules, particularly proteins. The advanced glycation end products can adversely affect the fuction of these macromolecules. One of the most prevalent AGE products, N-epsilon-(Carboxymethyl) Lysine, has been implicated in oxidative stress and vascular damage. The OxiSelect？ N-epsilon-(Carboxymethyl) Lysine Competitive ELISA kit specifically detects CML formation with a high level of sensitivity. This is a Competitive ELISA Kit in which the plate is coated with a CML conjugate.？ Standards and unknown samples are added to the plate, followed by incubation with the primary antibody. The CML in the unknown samples and the CML attached to the plate compete for the primary antibody. Higher CML content in unknown samples results in more binding of the antibody to the sample, and thus less antibody binds to the plate. Since the antibody bound to the sample is washed away, higher CML content in samples correlates with a lower signal.
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| 参考文献 |
Na+/K+-ATPase interaction with methylglyoxal as reactive metabolic side product. Svrckova M, et.al., Free Radic Biol Med. 2017 Jul;108:146-154. doi: 10.1016/j.freeradbiomed.2017.03.024. Epub 2017 Mar 22.
Regulatory landscape of AGE-RAGE-oxidative stress axis and its modulation by PPARγ activation in high fructose diet-induced metabolic syndrome. Cannizzaro L, et.al., Nutr Metab (Lond). 2017 Jan 13;14:5. doi: 10.1186/s12986-016-0149-z. eCollection 2017.
Effects of ferric citrate supplementation on advanced glycation end products in a rat model of streptozotocin/nicotinamide-induced diabetes. Chao KC, et.al., Mol Nutr Food Res. 2017 May;61(5). doi: 10.1002/mnfr.201600753. Epub 2017 Mar 21.
The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice. Hansen LM, t.al., Lab Invest. 2017 Jan;97(1):34-42. doi: 10.1038/labinvest.2016.113. Epub 2016 Nov 21.
Mediterranean Diet Supplemented With Coenzyme Q10 Modulates the Postprandial Metabolism of Advanced Glycation End Products in Elderly Men and Women. Lopez-Moreno J, et.al., J Gerontol A Biol Sci Med Sci. 2016 Oct 21. doi: 10.1093/gerona/glw214. [Epub ahead of print]
Advanced glycation of high-density lipoprotein and the functionality of aldosterone release in type 2 diabetes. Kuwano T, et.al., Hypertens Res. 2017 Mar;40(3):271-276. doi: 10.1038/hr.2016.141. Epub 2016 Oct 13.
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| メーカー |
品番 |
包装 |
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CBL
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STA-816
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96 ASSAY
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※表示価格について
| 当社在庫 |
なし
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| 納期目安 |
1週間程度
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| 法規制 |
劇・安
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| 保存温度 |
４℃と−２０℃
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