別包装 |
あり
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純度 |
>=98%
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分子量 |
634.61
|
CAS RN® |
1476-53-5
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化合物の概要 |
Aminocoumarin; bacterial DNA gyrase inhibitor.
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構造 |
C31H35N2NaO11
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溶媒 |
50mg/ml in water
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使用目的 |
Novobiocin is an aminocoumarin antibiotic that inhibits the ATPase activity of the B subunit of bacterial DNA gyrase. Novobiocin is most often used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. In addition to its antibacterial activity, novobiocin also displays anticancer chemotherapeutic and anti-angiogenic properties. Novoboicin inhibits HIF-1α binding to transcriptional coactivator p300/CBP in tumor models and analogs of this compound are in development as HSP90 inhibitors.
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参考文献 |
Gunaherath GM, Marron MT, Wijeratne EM, et al. Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors. Bioorg Med Chem. 2013 Sep 1;21(17):5118-29. PMID: 23859777.Wu D, Zhang R, Zhao R, et al. A novel function of novobiocin: disrupting the interaction of HIF 1α and p300/CBP through direct binding to the HIF1α C-terminal activation domain. PLoS One. 2013 May 6;8(5):e62014. PMID: 23671581.Walsh TJ, Standiford HC, Reboli AC, et al. Randomized Double-Blinded Trial of Rifampin with Either Novobiocin or Trimethoprim-Sulfamethoxazole against Methicillin-Resistant Staphylococcus aureus Colonization: Prevention of Antimicrobial Resistance and Effect of Host Factors on Outcome. Antimicrobial agents and chemotherapy 1993 Jun;37(6):1334-42. PMID: 8328783.Maxwell A. The interaction between coumarin drugs and DNA gyrase. Mol Microbiol 1993;9(4):681-6. PMID: 8231802.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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