別品名 |
Cyanidenon-4'-methyl ether 1479, Luteolin-4'-methyl ether, benzopyran-4-one
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別包装 |
あり
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純度 |
>=98%
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分子量 |
300.26
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CAS RN® |
520-34-3
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化合物の概要 |
O-methylated flavone found in vetch and various fruits.
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構造 |
C16H12O6
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溶媒 |
Sparingly soluble in water (<1 mg/ml). Soluble in acetonitrile, DMSO (60 mg/ml), and ethanol (17 mg/ml).
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使用目的 |
Diosmetin is an O-methylated flavone found in vetch and various citrus fruits; it exhibits antioxidative, anti-inflammatory, anticancer, and anti-osteoporotic activities. In animal models of AAPH-induced oxidative stress, diosmetin decreases generation of ROS and increases levels of superoxide dismutase, catalase, and glutathione peroxidase. Diosmetin also decreases amylase, lipase, TNF-α, IL-1β, IL-6, and iNOS in animal models of pancreatitis. In breast cancer cells, diosmetin induces G1 phase cell cycle arrest and inhibits cellular proliferation. Additionally, this compound increases activation of PKC, ERK1/2, and p38 MAPK, inducing osteoblastic differentiation in vitro.
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その他 |
[融点]257℃-259℃ [外観]Yellow Crystal Powder
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参考文献 |
Liao W, Ning Z, Chen L, et al. Intracellular Antioxidant Detoxifying Effects of Diosmetin on 2,2-Azobis(2-amidinopropane) Dihydrochloride (AAPH)-Induced Oxidative Stress through Inhibition of Reactive Oxygen Species Generation. J Agric Food Chem. 2014 Aug 27;62(34):8648-54. PMID: 25075433.Yu G, Wan R, Yin G, et al. Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2133-42. PMID: 24966921.Androutsopoulos VP, Mahale S, Arroo RR, et al. Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation. Oncol Rep. 2009 Jun;21(6):1525-8. PMID: 19424633.Hsu YL, Kuo PL. Diosmetin induces human osteoblastic differentiation through the protein kinase C/p38 and extracellular signal-regulated kinase 1/2 pathway. J Bone Miner Res. 2008 Jun;23(6):949-60. PMID: 18269307.
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メーカー |
品番 |
包装 |
LKT
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D3356
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250 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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