別品名 |
K+ channel toxin α-KTx 3.2; AgTx-2; AgTx2
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別包装 |
あり
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由来詳細 |
Recombinant
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標識物 |
Carboxytetramethylrhodamine
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発現系 |
大腸菌
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純度 |
99%
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分子量 |
4673
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化合物の概要 |
A Potent Blocker of KV1.3 K+ Channels
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構造 |
C202H316N58O51S9
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形状 |
凍結乾燥品
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※サムネイル画像をクリックすると拡大画像が表示されます。
ManufacturerBioassayAlomone Labs Agitoxin-2-Cys-TAMRA retains the inhibitory characteristics of the wild type toxin. - A. KV?current inhibition by?Agitoxin-2?(#STA-420), (100nM, pink) and?Agitoxin-2-Cys-TAMRA?(#RTA-420-T), (100nM, blue) in KV1.3 transfected HEK-293 cells. Top: Time course of KV1.3 current amplitude is presented. Currents were elicited from holding potential of -100 mV by 200 ms voltage pulses to +50 mV, every 10 seconds. Bottom: Superimposed traces taken from the same experiment shown on top, before (black) or during toxin perfusion (pink or blue).B. Dose response of KV1.3 current inhibition in?Xenopus?oocytes for Agitoxin-2, Agitoxin-2-Cys-TAMRA and Agitoxin-2-Cys. Top: time course of current amplitude, upon toxin perfusion. Currents were elicited from resting potential of -100 mV, by a 100 ms test pulse to 0 mV, delivered every 10 seconds. The bars above the plot represent periods of toxin perfusion, for each toxin sequential applications of the following concentrations: 1, 10, 50 and 100 nM, where the toxin species is indicated. Middle: Superimposed traces representing currents under control conditions (black) and during perfusion of 100 nM toxin: Agitoxin-2-Cys-TAMRA (orange), Agitoxin-2 (blue) and Agitoxin-2-Cys (green). Bottom: Dose response of toxins on current inhibition (n = 3 for each toxin, mean and SD). See inset for color coding.
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ManufacturerBioassayAlomone Labs Agitoxin-2-Cys-TAMRA retains the inhibitory characteristics of the wild type toxin. - A. KV?current inhibition by?Agitoxin-2?(#STA-420), (100nM, pink) and?Agitoxin-2-Cys-TAMRA?(#RTA-420-T), (100nM, blue) in KV1.3 transfected HEK-293 cells. Top: Time course of KV1.3 current amplitude is presented. Currents were elicited from holding potential of -100 mV by 200 ms voltage pulses to +50 mV, every 10 seconds. Bottom: Superimposed traces taken from the same experiment shown on top, before (black) or during toxin perfusion (pink or blue).B. Dose response of KV1.3 current inhibition in?Xenopus?oocytes for Agitoxin-2, Agitoxin-2-Cys-TAMRA and Agitoxin-2-Cys. Top: time course of current amplitude, upon toxin perfusion. Currents were elicited from resting potential of -100 mV, by a 100 ms test pulse to 0 mV, delivered every 10 seconds. The bars above the plot represent periods of toxin perfusion, for each toxin sequential applications of the following concentrations: 1, 10, 50 and 100 nM, where the toxin species is indicated. Middle: Superimposed traces representing currents under control conditions (black) and during perfusion of 100 nM toxin: Agitoxin-2-Cys-TAMRA (orange), Agitoxin-2 (blue) and Agitoxin-2-Cys (green). Bottom: Dose response of toxins on current inhibition (n = 3 for each toxin, mean and SD). See inset for color coding.
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メーカー |
品番 |
包装 |
ALO
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RTA-420-T
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1 UG
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※表示価格について
当社在庫 |
なし
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納期目安 |
約10日
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保存温度 |
-20℃
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