別品名 |
NA 209A, TR1
|
別包装 |
あり
|
純度 |
>=95%
|
分子量 |
511.57
|
CAS RN® |
12771-72-1
|
化合物の概要 |
Mycotoxin produced by Aspergillus; BK K+ channel blocker, GABA-A antagonist.
|
構造 |
C27H33N3O7
|
溶媒 |
DMSO, Methanol, Ethanol
|
使用目的 |
Verruculogen is a mycotoxin initially produced by species of Aspergillus; it is considered a tremorgenic indole alkaloid and may induce development of neurological disorders. Verruculogen inhibits Ca2+-activated K+ (BK) channels and may also act as an antagonist on GABA-A receptors, binding at or near the Cl- channel.
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その他 |
[融点]230-233℃
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参考文献 |
Smith RC, McClure MC, Smith MA, et al. The role of voltage-gated potassium channels in the regulation of mouse uterine contractility. Reprod Biol Endocrinol. 2007 Nov 2;5:41. PMID: 17980032.Kosalec I, Klaric MS, Pepeljnjak S. Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres. Acta Pharm. 2005 Dec;55(4):357-64. PMID: 16375825.Knaus HG, McManus OB, Lee SH, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 1994 May 17;33(19):5819-28. PMID: 7514038.Gant DB, Cole RJ, Valdes JJ, et al. Action of tremorgenic mycotoxins on GABAA receptor. Life Sci. 1987 Nov 9;41(19):2207-14. PMID: 2444852.
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メーカー |
品番 |
包装 |
LKT
|
V1870
|
1 MG
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※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
4℃
|
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