別品名 |
ZD6474, CH331
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別包装 |
あり
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純度 |
>=98%
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分子量 |
475.35
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CAS RN® |
443913-73-3
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化合物の概要 |
RET, EGFR, VEGFR2 inhibitor.
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構造 |
C22H24BrFN4O2
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使用目的 |
Vandetanib is an anticancer chemotherapeutic and anti-angiogenic compound that acts as an ATP-competitive inhibitor of RET, EGFR, and VEGFR2. In a cellular model of medullary thyroid carcinoma, vandetanib inhibits phosphorylation of RET, Shc, and MAPKs, inhibiting cell proliferation. In glioblastoma cells, vandetanib induces autophagy and apoptosis, and in a similar in vivo model, prevents tumor growth. In separate animal models, vandetanib’s inhibition of VEGFR2 decreases tumor microvessel density and tumor cell proliferation. Vandetanib also induces hypertension and prolongs the cardiac QT interval in clinical settings.
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参考文献 |
Liu Y, Liu Y, Fan ZW, et al. Meta-analysis of the risks of hypertension and QTc prolongation in patients with advanced non-small cell lung cancer who were receiving vandetanib. Eur J Clin Pharmacol. 2015 May;71(5):541-7. PMID: 25753291Shen J, Zheng H, Ruan J, et al. Autophagy inhibition induces enhanced proapoptotic effects of ZD6474 in glioblastoma. Br J Cancer. 2013 Jul 9;109(1):164-71. PMID: 23799852.Samadi AK, Bazzill J, Zhang X, et al. Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway. Surgery. 2012 Dec;152(6):1238-47. PMID: 23158190.Vitagliano D, De Falco V, Tamburrino A, et al. The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells. Endocr Relat Cancer. 2010 Nov 30;18(1):1-11. PMID: 20943719.Yano S, Muguruma H, Matsumori Y, et al. Antitumor vascular strategy for controlling experimental metastatic spread of human small-cell lung cancer cells with ZD6474 in natural killer cell-depleted severe combined immunodeficient mice. Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8789-98. PMID: 16361567.
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メーカー |
品番 |
包装 |
LKT
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V0352
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5 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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