別品名 |
Sodium 2-propylpentanoate, Sodium valproate, 2-Propylpentanoic acid sodium salt
|
別包装 |
あり
|
純度 |
>=98%
|
分子量 |
166.19
|
CAS RN® |
1069-66-5
|
化合物の概要 |
T-type Ca2+ and voltage-gated Na+ channel blocker, GABA transaminase and HDAC inhibitor.
|
構造 |
C8H15NaO2
|
溶媒 |
Water (50 mg/ml)Ethanol (30 mg/ml)DMSO (5 mg/ml)DMF (5 mg/ml)
|
使用目的 |
Valproic acid acts as an antagonist at T-type voltage-gated Ca2+ channels and voltage-gated Na+ channels; it also inhibits GABA transaminase, potentiating GABA signaling. Valproic acid is used clinically as an antiepileptic/anticonvulsant, although it also exhibits anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. Valproic acid may also display antihypertensive benefit. In lung tissue, this compound prevents LPS-induced increases in TNF-α, IL-1β, NF-κB, NO, and iNOS. Valproic acid is an inhibitor of class I histone deacetylases (HDACs), primarily active against HDAC1, and downregulates expression of HDAC, VEGF, VEGFR2, and FGF, inhibiting tumor growth and angiogenesis in animal models.
|
その他 |
[融点]300 oC
|
参考文献 |
Zhang ZH, Hao CL, Liu P, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2014 Feb;9(2):443-9. PMID: 24297248.Ji MH, Li GM, Jia M, et al. Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2013 Dec;36(6):1453-9. PMID: 23846716.Zhao L, Chen CN, Hajji N, et al. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation. 2012 Jul 24;126(4):455-67. PMID: 22711276.Rosenberg G. The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci. 2007 Aug;64(16):2090-103. PMID: 17514356.Kelly KM, Gross RA, Macdonald RL. Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons. Neurosci Lett. 1990 Aug 14;116(1-2):233-8. PMID: 2175404.
|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
メーカー |
品番 |
包装 |
LKT
|
V0147
|
10 G
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
法規制 |
安
|
保存温度 |
常温
|
|