別品名 |
Achromycin, Panmycin, Topicycline, Cylcopar, Diocyclin, [4S-(4α, 4aα, 5aα,6β,12aα)]-4-(Dimethylamino)- 1,4,4a,5,5a,6-11,12a-octahydro-3,6,10,12,12a-penta- hydroxy-6-methyl-1,11-dioxo-2-naphthacene- carboxamide hydrochloride
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別包装 |
あり
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純度 |
>=96%
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分子量 |
480.9
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CAS RN® |
64-75-5
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化合物の概要 |
Polyketide; protein translation inhibitor, mammalian RNA splicing inhibitor, potential MMP inhibitor.
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構造 |
C22H24N2O8 HCl
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溶媒 |
Soluble in water (100 mg/mL), methanol and ethanol (10 mg/mL). Insoluble in ether and hydrocarbons.
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使用目的 |
Tetracycline is a polyketide antibiotic originally produced by Streptomyces that exhibits antibacterial and neuroprotective activities. Tetracycline binds the 30S subunit of the bacterial ribosome, preventing aminoacyl-tRNA from binding to the ribosomal A site and inhibiting protein synthesis. Tetracycline is clinically used to treat acne, rosacea, Lyme disease, and various bacterial infections. Tetracycline binds amyloid-β (Aβ) peptides, increasing their solubility and decreasing their neurotoxicity in vitro. Tetracycline may also inhibit matrix metalloproteinases (MMPs). Additionally, tetracycline inhibits mammalian RNA splicing.
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その他 |
[融点]220℃-223℃ [外観]Yellow Crystalline Powder
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参考文献 |
Kennedy R, Alibhai M, Shakib K. Tetracycline: a cure all? Br J Oral Maxillofac Surg. 2014 Apr;52(4):382-3. PMID: 24613100.Mahajan GB, Balachandran L. Antibacterial agents from actinomycetes - a review. Front Biosci (Elite Ed). 2012 Jan 1;4:240-53. PMID: 22201868.Airoldi C, Colombo L, Manzoni C, et al. Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction. Org Biomol Chem. 2011 Jan 21;9(2):463-72. PMID: 21063627.Griffin MO, Fricovsky E, Ceballos G, et al. Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. PMID: 20592239.Hertweck M, Hiller R, Mueller MW. Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro. Eur J Biochem. 2002 Jan;269(1):175-83. PMID: 11784311.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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