別品名 |
Qari, Monos, Tebraxin, 9-Fluro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7- oxo-7H-pyridol[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid hydrochloride
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別包装 |
あり
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純度 |
>=98%
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分子量 |
399.87
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CAS RN® |
106017-08-7
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化合物の概要 |
Fluoroquinolone; topoisomerase IV and bacterial DNA gyrase inhibitor.
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構造 |
C17H18FN3O3S HCl
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使用目的 |
Rufloxacin is a fluoroquinolone antibiotic that exhibits antibacterial activity against both gram negative and gram positive bacteria such as Escherichia and Helicobacter. Rufloxacin inhibits topoisomerase IV and DNA gyrase. Under UV exposure, rufloxacin induces type II guanine oxidation, increasing DNA base oxidation and displaying mutagenic/carcinogenic potential.
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その他 |
[融点]322℃-324℃
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参考文献 |
Gu LY, Lin WW, Lu H, et al. Quadruple therapy with medications containing either rufloxacin or furazolidone as a rescue regimen in the treatment of Helicobacter pylori-infected dyspepsia patients: a randomized pilot study. Helicobacter. 2011 Aug;16(4):284-8. PMID: 21762267.Belvedere A, Bosca F, Catalfo A, et al. Type II guanine oxidation photoinduced by the antibacterial fluoroquinolone Rufloxacin in isolated DNA and in 2'-deoxyguanosine. Chem Res Toxicol. 2002 Sep;15(9):1142-9. PMID: 12230407.Montanari MP, Prenna M, Mingoia M, et al. In vitro antibacterial activity of trovafloxacin and five other fluoroquinolones. Chemotherapy. 1998 Mar-Apr;44(2):85-93. PMID: 9551237.
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メーカー |
品番 |
包装 |
LKT
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R8122
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25 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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