別品名 |
8-β-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-(9CI)4H-1-Benzopyran-4-one
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別包装 |
あり
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純度 |
>=96%
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分子量 |
416.38
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CAS RN® |
3681-99-0
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化合物の概要 |
Isoflavone daidzein derivative found in Pueraria; GABA-A potentiator, 5-HT2C antagonist.
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構造 |
C21H20O9
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溶媒 |
Soluble in methanol. Slightly soluble in ethanol.
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使用目的 |
Puerarin is an isoflavone derivative of daidzein found in Pueraria (Radix); it exhibits anxiolytic, cardioprotective, neuroprotective, and antioxidative activities. This compound also acts as a phytoestrogen. Puerarin acts as an antagonist at 5-HT2C receptors and at the benzodiazepine site on GABA-A receptors. Puerarin increases social interaction time and locomotor activity in animal models of substance withdrawal and inhibits cognitive impairment in the Morris water maze paradigm in animal models of Alzheimer’s disease. Additionally, puerarin decreases systolic blood pressure and heart rate and downregulates expression of P2X3 receptors in animal models of myocardial ischemia/reperfusion. This compound also protects neurons against H2O2-induced oxidative stress in vitro.
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その他 |
[融点]187℃ [外観]White powder with yellow cast
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参考文献 |
Liu S, Yu S, Xu C, et al. Puerarin alleviates aggravated sympathoexcitatory response induced by myocardial ischemia via regulating P2X3 receptor in rat superior cervical ganglia. Neurochem Int. 2014 May;70:39-49. PMID: 24657446.Zhou Y, Xie N, Li L, et al. Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. Int J Neuropsychopharmacol. 2014 Apr;17(4):635-44. PMID: 24345484.Zhang Q, Huang WD, Lv XY, et al. Puerarin protects differentiated PC12 cells from H2O2-induced apoptosis through the PI3K/Akt signalling pathway. Cell Biol Int. 2012 May 1;36(5):419-26. PMID: 22126839.Overstreet DH, Kralic JE, Morrow AL, et al. NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. Pharmacol Biochem Behav. 2003 Jun;75(3):619-25. PMID: 12895679.
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メーカー |
品番 |
包装 |
LKT
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P8118
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500 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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