別品名 |
Ficusin
|
別包装 |
あり
|
純度 |
>=98%
|
分子量 |
186.16
|
CAS RN® |
66-97-7
|
化合物の概要 |
Furanocoumarin found in Psoralea coryfolia, DNA cross-linker; topoisomerase I inhibitor.
|
構造 |
C11H6O3
|
溶媒 |
Soluble in ethanol (10 mg/ml), ethyl acetate, acetone, and water (1.93 mg/ml at 25 °C).
|
使用目的 |
Psoralen is a furanocoumarin compound originally found in Psoralea coryfolia that exhibits anti-angiogenic activity. Psoralen is currently used to treat psoriasis with the additional of UVA light. Psoralen inhibits angiogenesis and induces G0/G1 phase cell cycle arrest and apoptosis in endothelial cells. This compound also inhibits topoisomerase I and induces DNA interstrand crosslinks and monoadducts, displaying carcinogenic potential as well.
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その他 |
[融点]163-164 ℃ [沸点]362-363℃
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参考文献 |
Chopra B, Dhingra AK, Dhar KL. Psoralea corylifolia L. (Buguchi) - folklore to modern evidence: review. Fitoterapia. 2013 Oct;90:44-56. PMID: 23831482.Diwan R, Malpathak N. Furanocoumarins: novel topoisomerase I inhibitors from Ruta graveolens L. Bioorg Med Chem. 2009 Oct 1;17(19):7052-5. PMID: 19736019.Derheimer FA, Hicks JK, Paulsen MT, et al. Psoralen-induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related-dependent manner. Mol Pharmacol. 2009 Mar;75(3):599-607. PMID: 19064630.Deng H, Yan CL, Hu Y, et al. Photochemotherapy inhibits angiogenesis and induces apoptosis of endothelial cells in vitro. Photodermatol Photoimmunol Photomed. 2004 Aug;20(4):191-9. PMID: 15238097.
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メーカー |
品番 |
包装 |
LKT
|
P7358
|
10 MG
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※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
常温
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