別品名 |
Biltricide, Cesol, Droncit, 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
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別包装 |
あり
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純度 |
>=98%
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分子量 |
312.41
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CAS RN® |
55268-74-1
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化合物の概要 |
Alters membrane permeability and Ca2+ signaling; potential adenosine antagonist, potential voltage-gated Ca2+ channel blocker.
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構造 |
C19H24N2O2
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溶媒 |
Soluble in ethanol or chloroform.
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使用目的 |
Praziquantel is an anti-parasitic/anti-helminthic that is commonly used to treat schistosomiasis. Praziquantel increases membrane permeability, altering intracellular Ca2+ levels and inducing neuromuscular paralysis in parasites. Praziquantel may inhibit adenosine uptake and voltage-gated Ca2+ channels. In animal models, praziquantel reverses Schistosoma-induced hypertension and vascular remodeling.
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その他 |
[融点]136℃-138℃ [外観]White Crystal Powder
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参考文献 |
Cioli D, Pica-Mattoccia L, Basso A, et al. Schistosomiasis control: praziquantel forever? Mol Biochem Parasitol. 2014 Jun 21;195(1):23-29. PMID: 24955523.Chan JD, Zarowiecki M, Marchant JS. Ca2+ channels and praziquantel: a view from the free world. Parasitol Int. 2013 Dec;62(6):619-28. PMID: 23246536.Crosby A, Jones FM, Kolosionek E, et al. Praziquantel reverses pulmonary hypertension and vascular remodeling in murine schistosomiasis. Am J Respir Crit Care Med. 2011 Aug 15;184(4):467-73. PMID: 21659614.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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