別品名 |
Alprostadil, PGE1, Caverject, Muse, Prostandin, Prostin VR, (11a,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid
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別包装 |
あり
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純度 |
>=98%
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分子量 |
354.48
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CAS RN® |
745-65-3
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化合物の概要 |
Endogenous prostaglandin, vasodilator.
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構造 |
C20H34O5
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溶媒 |
Soluble in ethanol (5mg/mL) or acetone (10mg/mL).
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使用目的 |
Prostaglandin E1 (PGE1) is an endogenous prostaglandin synthesized from linolenic acid. PGE1 is clinically used for its vasodilatory activity as a treatment for erectile dysfunction. PGE1 also exhibits nephroprotective and pro-angiogenic activities. PGE1 decreases small intestine mucosa lesions in animal models of intestinal ischemia/reperfusion. PGE1 also improves renal function in subject with renal dysfunction or renal failure. Additionally, PGE1 enhances VEGF production in animal models of ischemia.
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その他 |
[融点]115℃-116℃
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参考文献 |
Hanchanale V, Eardley I. Alprostadil for the treatment of impotence. Expert Opin Pharmacother. 2014 Feb;15(3):421-8. PMID: 24369066.Brasileiro JL, Inoye CM, Aydos RD, et al. Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1. Acta Cir Bras. 2013 Nov;28(11):767-73. PMID: 24316743.Liu WJ, Zhang BC, Guo R, et al. Renoprotective effect of alprostadil in combination with statins in patients with mild to moderate renal failure undergoing coronary angiography. Chin Med J (Engl). 2013;126(18):3475-80. PMID: 24034093.Inoue H, Aihara M, Tomioka M, et al. Specific enhancement of vascular endothelial growth factor (VEGF) production in ischemic region by alprostadil--potential therapeutic application in pharmaceutical regenerative medicine. J Pharmacol Sci. 2013;122(2):158-61. PMID: 23728380.
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メーカー |
品番 |
包装 |
LKT
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P6956
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1 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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