別品名 |
4-Amino-1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine
|
別包装 |
あり
|
純度 |
>=98%
|
分子量 |
281.36
|
CAS RN® |
172889-26-8
|
化合物の概要 |
Src inhibitor.
|
構造 |
C16H19N5
|
溶媒 |
DMSO (25mg/ml), slightly soluble in ethanol
|
使用目的 |
PP-1 inhibits members of the Src kinase family and displays antioxidative, anti-inflammatory, and anti-arrhythmic characteristics. In an in vitro model of oxidative stress, PP-1 inhibits hydrogen peroxide-induced production of macrophage migration inhibitory factor (MIF). PP-1 decreases total and phosphorylated levels of Src and increases connexin-43 levels and gap junction communication. Additionally, PP-1 decreases ventricular tachycardia and sudden death in animal models of arrhythmia.
|
参考文献 |
Rao F, Deng CY, Zhang QH, et al. Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor induced by H2O2 in HL-1 mouse cardiac muscle cells. Braz J Med Biol Res. 2013 Sep;46(9):746-51. PMID: 24036910.Sovari AA, Iravanian S, Dolmatova E, et al. Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol. 2011 Nov 22;58(22):2332-9. PMID: 22093512.Wijetunge S, Hughes AD. Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus. J Hypertens. 2007 Sep;25(9):1871-8. PMID: 17762651.
|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
メーカー |
品番 |
包装 |
LKT
|
P6232
|
25 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
4℃
|
|