別包装 |
あり
|
純度 |
>=98%
|
分子量 |
933.13
|
CAS RN® |
80418-24-2
|
化合物の概要 |
Triterpene saponin found in species of Panax.
|
構造 |
C47H80O18
|
溶媒 |
Soluble in DMSO.
|
使用目的 |
Notoginsenoside R1 is a triterpene saponin originally found in species of Panax (ginseng) that exhibits neuroprotective, anti-atherosclerotic, anti-inflammatory, anti-hyperlipidemic, and immunostimulatory activities. Notoginsenoside R1 decreases amyloid-β-induced oxidative damage and MAPK signaling, improving cell viability in cellular models of Alzheimer’s disease. In ApoE knockout animals, notoginsenoside R1 increases expression of glutathione and superoxide dismutase and decreases expression of inflammatory cytokines; it also decreases LDL, triglyceride, and cholesterol levels and increases HDL levels, preventing atherosclerotic lesions. This compound also increases antigen-induced spleenocyte proliferation and IgG titers in vivo.
|
その他 |
[外観]White Powder
|
参考文献 |
Ma B, Meng X, Wang J, et al. Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation. Int Immunopharmacol. 2014 Jun 24;22(1):151-159. PMID: 24975829.Jia C, Xiong M, Wang P, et al. Notoginsenoside R1 Attenuates Atherosclerotic Lesions in ApoE Deficient Mouse Model. PLoS One. 2014 Jun 16;9(6):e99849. PMID: 24933211.Sun HX, Chen Y, Ye Y. Ginsenoside Re and notoginsenoside R1: Immunologic adjuvants with low haemolytic effect. Chem Biodivers. 2006 Jul;3(7):718-26. PMID: 17193304.
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メーカー |
品番 |
包装 |
LKT
|
N5778
|
10 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
4℃
|
|