別包装 |
あり
|
純度 |
>=95%, TLC
|
分子量 |
736.93
|
CAS RN® |
6833-84-7
|
化合物の概要 |
Naturally-ocurring neurtral cyclic ionophore, metal ion carrier; oxidative phosphorylation uncoupler.
|
構造 |
C40H64O12
|
溶媒 |
methanol, dichloromethane, ethyl acetate, DMSO
|
使用目的 |
Nonactin is a neutral cyclic ionophore that acts as an alkali metal ion carrier, transporting cargo such as Na+, K+, and NH4+ across lipid bilayers. Nonactin is a macrotetrolide antibiotic, although it does not exhibit antibacterial activity. Nonactin is naturally found in species of Streptomyces. This ionophore suppresses intracellular glycosylation and inhibits several trafficking pathways in virus-infected cells. Nonactin also uncouples oxidative phosphorylation in mitochondria.
|
その他 |
[融点]145-148℃
|
参考文献 |
Lee JM, Kim JG, Kim TH, et al. Nonactin hinders intracellular glycosylation in virus-infected baby hamster kidney cells. Mol Med Rep. 2010 Jan-Feb;3(1):115-9. PMID: 21472209.Bala S, Kombrabail MH, Prabhananda BS. Effect of phloretin on ionophore mediated electroneutral transmembrane translocations of H(+), K(+) and Na(+) in phospholipid vesicles. Biochim Biophys Acta. 2001 Feb 9;1510(1-2):258-69. PMID: 11342163.Vareille G, Marion P, Kraus JL, et al. Sodium transport by an ionizable and a neutral mobile carrier: effects of membrane structure on the apparent activation energy. Biochim Biophys Acta. 1993 Feb 23;1146(1):25-37. PMID: 8443224.Ginsburg H, Stark G. Facilitated transport of di- and trinitrophenolate ions across lipid membranes by valinomycin and nonactin. Biochim Biophys Acta. 1976 Dec 14;455(3):685-700. PMID: 1036715.
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|
メーカー |
品番 |
包装 |
LKT
|
N5652
|
1 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
4℃
|
|