別品名 |
Lincomycin hydrochloride monohydrate, Albiotic, Cillimycin, Lincomix, (2S-trans)-Methyl6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]-amino]-1-thio-D-erythro-α- D-galacto-octopyranoside hydrochloride monohydrate
|
別包装 |
あり
|
純度 |
>=89%
|
分子量 |
461.01
|
CAS RN® |
7179-49-9
|
化合物の概要 |
Lincosamide; peptidyl transferase inhibitor, protein translation inhibitor.
|
構造 |
C18H34N2O6S HCl H2O
|
溶媒 |
Soluble in water (50mg/mL).
|
使用目的 |
Lincomycin is a lincosamide antibiotic found in Streptomyces. Lincomycin exhibits antibacterial activity by binding the bacterial 50S ribosome subunit, inhibiting peptidyl transferase, and inducing dissociation of peptidyl-tRNA from the ribosome. Lincomycin also displays anti-parasitic/antimalarial activity against Plasmodium.
|
その他 |
[融点]156℃-158℃
|
参考文献 |
Tenson T, Lovmar M, Ehrenberg M. The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J Mol Biol. 2003 Jul 25;330(5):1005-14. PMID: 12860123.Menninger JR. Mechanism of inhibition of protein synthesis by macrolide and lincosamide antibiotics. J Basic Clin Physiol Pharmacol. 1995;6(3-4):229-50. PMID: 8852269.
|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
4℃
|
|