別品名 |
Kanamycin, D-Streptamine,O-3-amino-3-deoxy-alpha-D- glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D- glucopyranosyl-(1-4))-2-deoxy-
|
別包装 |
あり
|
純度 |
>=98%
|
分子量 |
582.58
|
CAS RN® |
25389-94-0
|
化合物の概要 |
Aminoglycoside; protein translation inhibitor, mammalian RNA splicing inhibitor.
|
構造 |
C18H36N4O11
|
溶媒 |
Soluble in water (100mM) or alcohol.
|
使用目的 |
Kanamycin A is an aminoglycoside antibiotic that binds the bacterial 16s rRNA subunit, inhibiting translocation and degrading target RNA; it displays antibacterial efficacy against gram negative bacteria. Kanamycin also prevents formation of the initiation complex. Kanamycin A also inhibits mammalian RNA splicing.
|
その他 |
[沸点]809.5℃
|
参考文献 |
Romanowska J, Reuter N, Trylska J. Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes. Proteins. 2013 Jan;81(1):63-80. PMID: 22907688.Patwardhan A, Cowan JA. Influence of charge and structure on the coordination chemistry of copper aminoglycosides. Dalton Trans. 2011 Feb 28;40(8):1795-801. PMID: 21218243.Aukema KG, Chohan KK, Plourde GL, et al. Small molecule inhibitors of yeast pre-mRNA splicing. ACS Chem Biol. 2009 Sep 18;4(9):759-68. PMID: 19634919.
|
※サムネイル画像をクリックすると拡大画像が表示されます。
|
|
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
常温
|
|