別品名 |
D-Glucosamine HCl,2-Amino-2-deoxy-D-glucopyranose hydrochloride, Chitosamine hydrochloride, 2-Amino-2-deoxy-D-glucose hydrochloride
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別包装 |
あり
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純度 |
>=96%
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分子量 |
215.6
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CAS RN® |
66-84-2
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化合物の概要 |
Endogenous amino sugar precursor required for production of cartilage.
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構造 |
C6H13NO5 HCl
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溶媒 |
Soluble in water.
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使用目的 |
Glucosamine is an endogenous amino sugar precursor to glycosylated protein and lipid formation; it is used in the making of cartilage. Glucosamine improves joint function and is often found in dietary supplements. Glucosamine exhibits anticancer and anti-fibrotic activities. In prostate cancer cells, glucosamine decreases N-glycosylation of gp130, suppressing binding of IL-6, phosphorylation of JAK2, SHP2, and STAT3, and cellular proliferation. Additionally, glucosamine decreases TGF-β1-induced expression of collagen I, fibronectin, and αSMA, inhibits phosphorylation of Smad2/3, and suppresses the development of renal fibrosis in vivo.
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その他 |
[融点]190℃-194℃ [外観]White Crystal Powder
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参考文献 |
Chesnokov V, Gong B, Sun C, et al. Anti-cancer activity of glucosamine through inhibition of N-linked glycosylation. Cancer Cell Int. 2014 May 28;14:45. PMID: 24932134.Park J, Lee SY, Ooshima A, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84. PMID: 24072041.
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メーカー |
品番 |
包装 |
LKT
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G4580
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500 G
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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