別品名 |
Amebacilin, Fugillin, Fumadil B: Fumidil, [3R-[3α,4α(2R*,3R*),5β,6β(all-E)]]-2,4,6,8-Decatetra- enedioic acid, mono[5-methoxy-4-[2-methyl-3-(3- methyl- 2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] ester
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別包装 |
あり
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純度 |
>=98%
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分子量 |
458.54
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CAS RN® |
23110-15-8
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化合物の概要 |
Produced by Aspergillus; type 2 methionine aminopeptidase inhibitor.
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構造 |
C26H34O7
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溶媒 |
Soluble in most organic solvents. Practically insoluble in water, dilute acids and saturated hydrocarbons.
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使用目的 |
Fumagillin is an antimicrobial compound initially produced by species of Aspergillus that exhibits anti-parasitic, antimalarial, anti-fibrotic, anti-angiogenic, and anticancer chemotherapeutic activities. Fumagillin is clinically used to treat microsporidiosis and displays efficacy against Plasmodium, Nosema, and Enterocytozoon. In vivo, fumagillin decreases pulmonary fibrosis, pulmonary hypertension, and ventricular remodeling. In cellular and animal models of colorectal cancer, fumagillin inhibits type 2 methionine aminopeptidase, preventing tube and vessel formation and well as cell proliferation, migration, and adhesion; it also decreases tumor mass.
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その他 |
[融点]194℃-195℃ [外観]Off white Powder
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参考文献 |
Kass DJ, Rattigan E, Kahloon R, et al. Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats. PLoS One. 2012;7(4):e35388. PMID: 22509410.Champion L, Durrbach A, Lang P, et al. Fumagillin for treatment of intestinal microsporidiosis in renal transplant recipients. Am J Transplant. 2010 Aug;10(8):1925-30. PMID: 20636462.Arico-Muendel C, Centrella PA, Contonio BD, et al. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5128-31. PMID: 19648008.Hou L, Mori D, Takase Y, et al. Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis. Pathol Int. 2009 Jul;59(7):448-61. PMID: 19563408.Chen X, Xie S, Bhat S, et al. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol. 2009 Feb 27;16(2):193-202. PMID: 19246010.
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メーカー |
品番 |
包装 |
LKT
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F8048
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1 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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