別品名 |
Doxycycline hydrochloride hemiethanolate hemihydrate, Atridox, Bassado, Clinofug, Doryx, Hydramycin, Mespafinn, Retens, Spanor, Unacil, Zadorin, [4S-(4α,4aα,5α,5aα,6α,12aα)]-4-(Dimethylamino)-1,-4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-penta- hydroxy-6-methyl-1,11-dioxo-2-naphthacenecarbox- amide hydrochloride hemiethanolate hemihydrate
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別包装 |
あり
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純度 |
>=97%
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分子量 |
512.9
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CAS RN® |
24390-14-5
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化合物の概要 |
Tetracycline; protein translation inhibitor, MMP inhibitor.
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構造 |
C22H24N2O8 HCl 1/2(H2O) 1/2(C2H6O)
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溶媒 |
Soluble in water 50 mg/mL; DMSO.
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使用目的 |
Doxycycline is a tetracycline antibiotic that exhibits anti-parasitic, anti-helminthic, anti-inflammatory, anticancer, and anti-metastatic activities. Doxycycline exerts its antibacterial activity through binding 16S rRNA of the bacterial 30S ribosome, preventing binding of aminoacyl-tRNA to the ribosomal A site, inhibiting translation. Doxycycline also inhibits matrix metalloproteinases (MMPs). Doxycycline displays slow antimalarial benefit, inhibiting expression of the apicoplast genome and inducing loss of function in parasites. This compound inhibits Wolbachia endosymbionts from Wucheria, inducing sterilization and inhibiting growth. Doxycycline improves pulmonary function and parameters of chronic obstructive pulmonary syndrome (COPD) in clinical settings. Additionally, doxycycline inhibits migration and proliferation of breast adenocarcinoma cells. Doxycycline also attenuates cardiac hypertrophy in vivo and displays anti-allergic and anti-asthma benefits, suppressing activation of IgE and upregulating expression of IL-2.
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その他 |
[融点]220℃-223℃
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参考文献 |
Joks R, Durkin HG. Non-antibiotic properties of tetracyclines as anti-allergy and asthma drugs. Pharmacol Res. 2011 Dec;64(6):602-9. PMID: 21501686.Dalvi PS, Singh A, Trivedi HR, et al. Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms. Ann Thorac Med. 2011 Oct;6(4):221-6. PMID: 21977068.Errami M, Galindo CL, Tassa AT, et al. Doxycycline attenuates isoproterenol- and transverse aortic banding-induced cardiac hypertrophy in mice. J Pharmacol Exp Ther. 2008 Mar;324(3):1196-203. PMID: 18089841.Dahl EL, Shock JL, Shenai BR, et al. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep;50(9):3124-31. PMID: 16940111.Hoerauf A, Mand S, Fischer K, et al. Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol. 2003 Nov;192(4):211-6. PMID: 12684759.Dursun D, Kim MC, Solomon A, et al. Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. Am J Ophthalmol. 2001 Jul;132(1):8-13. PMID: 11438047.Fife RS, Sledge GW Jr. Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells. J Lab Clin Med. 1995 Mar;125(3):407-11. PMID: 7897308.Fumoto T, Takeshita S, Ito M, Ikeda K. Physiological functions of osteoblast lineage and T cell-derived RANKL in bone homeostasis. J Bone Miner Res. 2014 Apr;29(4):830-842. PMID: 24014480.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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