別包装 |
あり
|
純度 |
>=98%
|
分子量 |
481.62
|
CAS RN® |
39156-67-7
|
化合物の概要 |
Mycotoxin derivative; actin polymerization inhibitor, Kv1.1-A-type K+ channel converter.
|
構造 |
C29H39NO5
|
溶媒 |
Acetone, DMSO, 100% Ethanol, Methanol
|
使用目的 |
Dihydrocytochalasin B is a mycotoxin derivative that inhibits actin polymerization, preventing mitosis. Dihydrocytochalasin B exhibits anti-parasitic activity, inhibiting the growth of Entamoeba invadens. Additionally, dihydrocytochalasin B exhibits neuromodulatory activity, enhancing the conversion of Kv1.1 K+ channels to A-type K+ channels.
|
その他 |
[融点]203-205oC
|
参考文献 |
Makioka A, Kumagai M, Kobayashi S, et al. Different effects of cytochalasins on the growth and differentiation of Entamoeba invadens. Parasitol Res. 2004 May;93(1):68-71. PMID: 15103555.Reshetnikova G, Barkan R, Popov B, et al. Disruption of the actin cytoskeleton leads to inhibition of mitogen-induced cyclin E expression, Cdk2 phosphorylation, and nuclear accumulation of the retinoblastoma protein-related p107 protein. Exp Cell Res. 2000 Aug 25;259(1):35-53. PMID: 10942577.Jing J, Chikvashvili D, Singer-Lahat D, et al. Fast inactivation of a brain K+ channel composed of Kv1.1 and Kvbeta1.1 subunits modulated by G protein beta gamma subunits. EMBO J. 1999 Mar 1;18(5):1245-56. PMID: 10064591.
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メーカー |
品番 |
包装 |
LKT
|
D3429
|
5 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
4℃
|
|