別品名 |
Citreoviridin, 4-Methoxy-5-methyl-6-(7-methyl-8-(tetrahydro-3,4-dihydroxy-2,4,5-trimethyl-2-furyl)-1,3,5,7-octatetraenyl)-2H-pyran-2-one
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別包装 |
あり
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純度 |
>=95%
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分子量 |
402.48
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CAS RN® |
25425-12-1
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化合物の概要 |
Mycotoxin; F1F0 ATP synthase inhibitor.
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構造 |
C23H30O6
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溶媒 |
Insoluble in water. Soluble in ethanol, chloroform, dichloromethane, and DMSO (10 mg/mL).
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使用目的 |
Citreoviridin A is a mycotoxin found in cereal and bread grains; it exhibits pro-oxidative, anticancer chemotherapeutic, antibacterial, antifungal, and antiviral activities. In vitro, citreoviridin A increases ROS levels and decreases glutathione, inducing oxidative stress, destabilizing the lysosome and mitochondria and causing DNA damage. Citreoviridin A inhibits the F1 subunit of F1F0 ATP synthase, inhibiting cell proliferation in a lung cancer xenograft model. Citreoviridin also increases phosphorylation of eIF2α, inducing the unfolded protein response and the inhibition of cell growth. In other cellular models, this compound increases TNF-α-induced cellular adhesion to monocytes, increases nuclear translocation of NF-κB, and increases expression of ICAM-1, VCAM-1, E-selectin, and MCP-1. Citreoviridin inhibits cellular growth in species of Bacillus and Candida and also inhibits replication of HIV-1.
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その他 |
[融点]110 ℃ [外観]Orange-yellow powder
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参考文献 |
Bai Y, Jiang LP, Liu XF, et al. The role of oxidative stress in citreoviridin-induced DNA damage in human liver-derived HepG2 cells. Environ Toxicol. 2013 Dec 6. [Epub ahead of print]. PMID: 24318808.Wu YH, Hu CW, Chien CW, et al. Quantitative proteomic analysis of human lung tumor xenografts treated with the ectopic ATP synthase inhibitor citreoviridin. PLoS One. 2013 Aug 21;8(8):e70642. PMID: 23990911.Hou H, Zhou R, Jia Q, et al. Citreoviridin enhances tumor necrosis factor-α-induced adhesion of human umbilical vein endothelial cells. Toxicol Ind Health. 2013 Mar 22. PMID: 23524880.Chang HY, Huang HC, Huang TC, et al. Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response. Cancer Res. 2012 Sep 15;72(18):4696-706. PMID: 22822083.Vieta I, Savarino A, Papa G, et al. In vitro inhibitory activity of citreoviridin against HIV-1 and an HIV-associated opportunist: Candida albicans. J Chemother. 1996 Oct;8(5):351-7. PMID: 8957714.Sayood SF, Suh H, Wilcox CS, et al. Effect of citreoviridin and isocitreoviridin on beef heart mitochondrial ATPase. Arch Biochem Biophys. 1989 May 1;270(2):714-21. PMID: 2523213.
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メーカー |
品番 |
包装 |
LKT
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C3576
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5 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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