別品名 |
Chondroitinsulfuric acid, Chonsurid, Structum, Chondroitin sulfate sodium
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別包装 |
あり
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種由来 |
Chicken
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純度 |
>=90%
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分子量 |
50000
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CAS RN® |
9082-07-9
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化合物の概要 |
Polyanionic sulfated glycosaminoglycan, endogenous component of connective tissues.
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構造 |
C13H21NO15S
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溶媒 |
Soluble in water.
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使用目的 |
Chondroitin sulfate (CS) is a polyanionic sulfated glycosaminoglycan that displays anti-arthritic, antioxidative, and anti-inflammatory activities. CS is an endogenous component of the extracellular matrix of connective tissues and is responsible for their resistance and elasticity. CS is often used as a dietary supplement, although its oral bioavailability is quite low (10-20%). In vivo, CS decreases synovitis and levels of IL-6, TNF-α, IL-1β, and myeloperoxidase. CS may act on toll-like receptor 4 (TLR4), preventing activation of NF-κB and inhibiting TNF receptor association factor 6 (TRAF6). In cellular and animal models, CS increases synthesis of collagen, proteoglycan, and hyaluronic acid; it also downregulates expression of matrix metalloproteinases 1, 3, and 13. In vitro, CS increases levels of glutathione and superoxide dismutase and inhibits activation of caspases 3 and 7, decreasing levels of ROS.
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その他 |
[融点]190℃-194℃
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参考文献 |
Henrotin Y, Mathy M, Sanchez C, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. PMID: 22870459.Campo GM, Avenoso A, Campo S, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92. PMID: 19009563.Campo GM, Avenoso A, Campo S, et al. Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice. Osteoarthritis Cartilage. 2008 Dec;16(12):1474-83. PMID: 18501644.Chou MM, Vergnolle N, McDougall JJ, et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med (Maywood). 2005 Apr;230(4):255-62. PMID: 15792947.Cho SY, Sim JS, Jeong CS, et al. Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice. Biol Pharm Bull. 2004 Jan;27(1):47-51. PMID: 14709897.Campo GM, Avenoso A, Campo S, et al. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther. 2003;5(3):R122-31. PMID: 12723984.Omata T, Itokazu Y, Inoue N, et al. Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung. 2000 Feb;50(2):148-53. PMID: 10719618.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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