別品名 |
Amiodar, Ancaron, Cordarone, Ortacrone, Tachydaron, Trangorex , (2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride
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別包装 |
あり
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純度 |
>=98%
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分子量 |
681.78
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CAS RN® |
19774-82-4
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化合物の概要 |
Voltage-gated Na+, Ca2+, K+ channel blocker, α/β-adrenergic antagonist, FIASMA.
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構造 |
C25H29I2NO3 HCl
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溶媒 |
Soluble in methanol, chloroform, and methylene chloride. Slightly soluble in acetone and dioxane. Sparingly soluble in isopropanol.
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使用目的 |
Amiodarone is a class III anti-arrhythmic that inhibits Na+ channels, voltage-gated Ca2+ channels, voltage-gated K+ channels, and α/β-adrenergic receptors. Amiodarone prolongs the duration of the action potential, increasing the length of the refractory period; it is clinically used to treat ventricular fibrillation and ventricular tachycardia. Amiodarone also exhibits antiviral activity, inhibiting cell entry by filovirus, guanarito virus, and hepatitis C. Additionally, this compound acts as a functional inhibitor of acid sphingomyelinase (FIASMA).
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その他 |
[融点]156℃ [外観]White or almost white Crystal Powder
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参考文献 |
Zoerner F, Semenas E. Resuscitation with amiodarone increases survival after hemorrhage and ventricular fibrillation in pigs. J Trauma Acute Care Surg. 2014 Jun;76(6):1402-8. PMID: 24854308.Gehring G, Rohrmann K, Atenchong N, et al. The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry. J Antimicrob Chemother. 2014 Apr 7. [Epub ahead of print]. PMID: 24710028.Cheng YL, Lan KH, Lee WP, et al. Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle. Clin Sci (Lond). 2013 Nov;125(9):439-48. PMID: 23659500.
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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法規制 |
安
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保存温度 |
4℃
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