別品名 |
AME; Djalonensone; Alternariol monomethyl ether; Alternariol methyl ether; Alternariol-9-methyl ether, 6H-Dibenzo(b,d)pyran-6-one, 3,7-dihydroxy-9-methoxy-1-methyl
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別包装 |
あり
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純度 |
>=98%
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分子量 |
272.25
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CAS RN® |
26894-49-5
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化合物の概要 |
Mycotoxin produced by Alternaria; oxidative phosphorylation inhibitor, potential ER agonist.
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構造 |
C15H12O5
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溶媒 |
Soluble in DMSO, ethanol, methanol
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使用目的 |
Alternariol 9-methyl ester (A9ME) is a highly toxic mutagenic phytotoxin initially produced by species of Alternaria. A9ME is present in grain and fruit used for livestock feed and human consumption. A9ME inhibits the electron transport chain, preventing photosynthesis in vitro. Additionally, A9ME may exhibit anticancer potential in a cellular model of colon carcinoma, as it decreases the mitochondrial membrane potential, increasing release of cytochrome c and activating caspases 3 and 9; this results in apoptosis and cell death.
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その他 |
[CAS RN(R).]23452-05-3
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参考文献 |
Demuner AJ, Barbosa LC, Miranda AC, et al. The Fungal Phytotoxin Alternariol 9-Methyl Ether and Some of Its Synthetic Analogues Inhibit the Photosynthetic Electron Transport Chain. J Nat Prod. 2013 Nov 18. [Epub ahead of print]. PMID: 24245962.Broggi L, Reynoso C, Resnik S, et al. Occurrence of alternariol and alternariol monomethyl ether in beverages from the Entre Rios Province market, Argentina. Mycotoxin Res. 2013 Feb;29(1):17-22. PMID: 23334721.Scott PM, Zhao W, Feng S, et al. Alternaria toxins alternariol and alternariol monomethyl ether in grain foods in Canada. Mycotoxin Res. 2012 Nov;28(4):261-6. PMID: 23087499.Bensassi F, Gallerne C, el Dein OS, et al. Mechanism of Alternariol monomethyl ether-induced mitochondrial apoptosis in human colon carcinoma cells. Toxicology. 2011 Dec 18;290(2-3):230-40. PMID: 22001388.
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メーカー |
品番 |
包装 |
LKT
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A4678
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5 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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