別品名 |
AZT, Azidothymidine, Zidovudine, ZDV, ZVD, 1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl- pyrimidine-2,4-dione
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別包装 |
あり
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純度 |
>=98%
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分子量 |
267.24
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CAS RN® |
30516-87-1
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化合物の概要 |
Nucleoside (thymidine) analog; DNA chain terminator.
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構造 |
C10H13N5O4
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溶媒 |
Soluble in water (50mg/mL).
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使用目的 |
AZT is a thymidine nucleoside analog that inhibits reverse transcriptase and is clinically used to treat HIV/AIDS. AZT inhibits viral DNA synthesis, preventing viral replication; at high doses, it may inhibit DNA polymerase. Use of AZT is often limited by hepatotoxicity and steatosis.
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その他 |
[融点]118-126oC [外観]Off-white crystalline powder
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参考文献 |
Banerjee A, Abdelmegeed MA, Jang S, et al. Zidovudine (AZT) and hepatic lipid accumulation: implication of inflammation, oxidative and endoplasmic reticulum stress mediators. PLoS One. 2013 Oct 11;8(10):e76850. PMID: 24146933.Parker WB, White EL, Shaddix SC, et al. Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs. J Biol Chem. 1991 Jan 25;266(3):1754-62. PMID: 1703154.Furman PA, Fyfe JA, St Clair MH, et al. Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7. PMID: 2430286.
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メーカー |
品番 |
包装 |
LKT
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A3212
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25 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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