別品名 |
Actinonine, 3-((1-((2-[Hydroxymethyl]-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamoyl)octanohydroxamic acid
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別包装 |
あり
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純度 |
>=98%
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分子量 |
385.5
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CAS RN® |
13434-13-4
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化合物の概要 |
Peptide deformylase, MMP meprin A, aminopeptidase N (CD13) inhibitor.
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構造 |
C19H35N3O5
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溶媒 |
Soluble in ethanol, DMSO, DMF, methanol, acetone. Insoluble in water.
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使用目的 |
Actinonin is an inhibitor of peptide deformylase, matrix metalloproteinase meprin A, and aminopeptidase N (CD13). Actinonin exhibits anticancer, antibiotic, anti-inflammatory, and nephroprotective activities. In Burkitt’s lymphoma cells, actinonin inhibits mitochondrial protein translation, inducing apoptosis. Actinonin exhibits antibacterial efficacy against many gram negative bacteria, including Mycobacterium. Additionally, in animal models of cecal ligation and puncture, actinonin decreases levels of IL-1β, preserving renal morphology and preventing alterations in renal capillary profusion and sepsis.
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その他 |
[融点]141.5-142oC
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参考文献 |
Sheth A, Escobar-Alvarez S, Gardner J, et al. Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers. Cell Death Dis. 2014 Mar 27;5:e1152. PMID: 24675470.Goemaere E, Melet A, Larue V, et al. New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity. J Antimicrob Chemother. 2012 Jun;67(6):1392-400. PMID: 22378679.Wang Z, Herzog C, Kaushal GP, et al. Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. Shock. 2011 Feb;35(2):141-7. PMID: 20577148.Sharma A, Sharma S, Khuller GK, et al. In vitro and ex vivo activity of peptide deformylase inhibitors against Mycobacterium tuberculosis H37Rv. Int J Antimicrob Agents. 2009 Sep;34(3):226-30. PMID: 19505802.Sina A, Lord-Dufour S, Annabi B. Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation. Cancer Lett. 2009 Jul 8;279(2):171-6. PMID: 19264392.
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メーカー |
品番 |
包装 |
LKT
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A0978
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5 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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