別品名 |
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d4; Baichanin A-d4; Bonistein-d4; 4',5,7-Trihydroxyisoflavone-d4; GeniVida-d4; Genisteol-d4; NSC 36586-d4; Prunetol-d4; Sophoricol-d4;
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分子量 |
274.26
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CAS RN® |
187960-08-3
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構造 |
C15H6D4O5
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溶媒 |
DMSO (Slightly), Methanol (Slightly)
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使用目的 |
Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
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その他 |
[融点]>275℃ (dec.) [性状]Light Yellow to Yellow Solid
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参考文献 |
Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)
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メーカー |
品番 |
包装 |
TRC
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G350010
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10 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
2週間程度
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保存温度 |
-20℃
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