Chondroitin sulfate Sodium Salt  

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別品名 Chondroitinsulfuric acid, Chonsurid, Structum
別包装 あり
種由来 Bovine
純度 >=90%
分子量 50000
CAS RN® 9082-07-9
化合物の概要 Polyanionic sulfated glycosaminoglycan, encogenoud component of connective tissues.
構造 C13H21NO15S
溶媒 Soluble in water.
使用目的 Chondroitin sulfate (CS) is a polyanionic sulfated glycosaminoglycan that displays anti-arthritic, antioxidative, and anti-inflammatory activities. CS is an endogenous component of the extracellular matrix of connective tissues and is responsible for their resistance and elasticity. CS is often used as a dietary supplement, although its oral bioavailability is quite low (10-20%). In vivo, CS decreases synovitis and levels of IL-6, TNF-α, IL-1β, and myeloperoxidase. CS may act on toll-like receptor 4 (TLR4), preventing activation of NF-κB and inhibiting TNF receptor association factor 6 (TRAF6). In cellular and animal models, CS increases synthesis of collagen, proteoglycan, and hyaluronic acid; it also downregulates expression of matrix metalloproteinases 1, 3, and 13. In vitro, CS increases levels of glutathione and superoxide dismutase and inhibits activation of caspases 3 and 7, decreasing levels of ROS.
その他 [融点]190℃-194℃
[外観]White to off white powder
参考文献 Henrotin Y, Mathy M, Sanchez C, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. PMID: 22870459.Campo GM, Avenoso A, Campo S, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92. PMID: 19009563.Campo GM, Avenoso A, Campo S, et al. Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice. Osteoarthritis Cartilage. 2008 Dec;16(12):1474-83. PMID: 18501644.Chou MM, Vergnolle N, McDougall JJ, et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med (Maywood). 2005 Apr;230(4):255-62. PMID: 15792947.Cho SY, Sim JS, Jeong CS, et al. Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice. Biol Pharm Bull. 2004 Jan;27(1):47-51. PMID: 14709897.Campo GM, Avenoso A, Campo S, et al. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther. 2003;5(3):R122-31. PMID: 12723984.Omata T, Itokazu Y, Inoue N, et al. Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung. 2000 Feb;50(2):148-53. PMID: 10719618.

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メーカー 品番 包装
LKT C2960 5 G
希望販売価格 ¥12,000

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当社在庫 なし
納期目安 1週間程度
保存温度 4℃

 

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メーカー情報
メーカー名 LKT Laboratories, Inc.
略号 LKT
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