| 別品名 |
hMAD 3 antibody, hSMAD3 antibody, MADH3 antibody, MGC60396 antibody, Mothers against decapentaplegic homolog 3 antibody, Mothers against DPP homolog 3 antibody
|
| 種由来 |
Human
|
| 標識物 |
Unlabeled
|
| 精製度 |
Affinity Purified
|
| 適用 |
Western Blot
Enzyme Linked Immunosorbent Assay
|
| 免疫動物 |
Rabbit
|
| 交差種 |
Mouse
|
| 翻訳後修飾 |
リン酸化
|
| GENE ID |
4088
|
| Accession No.(Gene/Protein) |
NP_005893, P84022
|
| Gene Symbol |
SMAD3
|
| 形状 |
滅菌済み液状品
|
| 参考文献 |
[Pub Med ID]24071738, 27912093, 26416749, 27210748, 27279422
|
|
※サムネイル画像をクリックすると拡大画像が表示されます。
The SMAD pathway follows the canonical TGF B signaling pathway. TGF B dimers bind to a receptor thereby activating the pathway. The type I receptor then recruits and phosphorylates a receptor regulated SMAD (R SMAD).i.e. SMAD2 or SMAD3. The R SMAD then binds to the common SMAD (coSMAD) i.e. SMAD4, and forms a heterodimeric complex. This complex then enters the cell nucleus and acts as a transcription factor.
NMuMG mouse mammary epithelial cells were probed for the activation of Smad3 by detecting phosphorylation of threonine 179. The cells were either untreated or treated with TGF-beta, transferred to membranes and probed with Anti-SMAD3 pT179 (RABBIT) Antibody. The antibody detects only Smad3 in stimulated cells suggesting detection of phosphorylated SMAD3 at T179.
|
|
|
|
The SMAD pathway follows the canonical TGF B signaling pathway. TGF B dimers bind to a receptor thereby activating the pathway. The type I receptor then recruits and phosphorylates a receptor regulated SMAD (R SMAD).i.e. SMAD2 or SMAD3. The R SMAD then binds to the common SMAD (coSMAD) i.e. SMAD4, and forms a heterodimeric complex. This complex then enters the cell nucleus and acts as a transcription factor.
|
|
|
| メーカー |
品番 |
包装 |
|
RKL
|
600-401-C48
|
100 UG
|
※表示価格について
| 当社在庫 |
なし
|
| 納期目安 |
約10日
|
| 保存温度 |
-２０℃
|
|
