別包装 |
あり
|
純度 |
>=90%
|
分子量 |
622.83
|
CAS RN® |
88899-55-2
|
化合物の概要 |
Macrolide antibiotic; vacuolar H+ ATPase inhibitor.
|
構造 |
C35H58O9
|
溶媒 |
Soluble in DMSO, ethanol and methanol.
|
使用目的 |
Bafilomycin A1 is a macrolide antibiotic initially produced by Streptomyces that exhibits anti-parasitic, antimalarial, and anticancer chemotherapeutic activities. Bafilomycin A1 inhibits the vacuolar H+ ATPase and suppresses autophagy. Bafilomycin kills Plasmodium parasites in cellular models, and separately, induces cell death and suppresses tumor growth in animal models of breast cancer.
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その他 |
[外観]White to off white powder
|
参考文献 |
Graham RM, Thompson JW, Webster KA. Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis. Oncotarget. 2014 Mar 15;5(5):1162-73. PMID: 24811485.Xu MY, Lee SY, Kang SS, et al. Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy. J Nat Prod. 2014 Feb 28;77(2):370-6. PMID: 24547878.van Schalkwyk DA, Chan XW, Misiano P, et al. Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death. Biochem Pharmacol. 2010 May 1;79(9):1291-9. PMID: 20067768.
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メーカー |
品番 |
包装 |
LKT
|
B0025
|
1 MG
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※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
-20℃
|
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