別品名 |
Arasaponin E1, Gypenoside III, Sanchinoside E1
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別包装 |
あり
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純度 |
>=98%
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分子量 |
1109.29
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CAS RN® |
41753-43-9
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化合物の概要 |
Triterpene saponin found in species of Panax.
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構造 |
C54H92O23
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溶媒 |
Soluble in water.Soluble in methanol or ethanol
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使用目的 |
Ginsenoside Rb1 is a triterpene saponin originally found in species of Panax that exhibits antioxidative, anti-inflammatory, neuroprotective, orexigenic, and stimulatory activities. In animal models, ginsenoside Rb1 increases motor activity, food intake, and skeletal muscle ATP content, improving energy metabolism. Ginsenoside Rb1 also downregulates expression of toll-like receptor 4 (TLR4) and TNF-α in animal models of sepsis, protecting against liver and lung damage. Additionally, ginsenoside Rb1 inhibits glucose-induced neurotoxicity by preventing GSK-3β-stimulated CHOP induction. This compound also activates Nrf2 and increases expression of heme oxygenase 1 (HO-1), suppressing oxidative stress in vitro.
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その他 |
[外観]White Powder[沸点]1146℃
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参考文献 |
Tan SJ, Li N, Zhou F, et al. Ginsenoside Rb1 improves energy metabolism in the skeletal muscle of an animal model of postoperative fatigue syndrome. J Surg Res. 2014 May 2. [Epub ahead of print]. PMID: 24881470.Wu LL, Jia BH, Sun J, et al. Protective effects of ginsenoside Rb1 on septic rats and its mechanism. Biomed Environ Sci. 2014 Apr;27(4):300-3. PMID: 24758759.Liu D, Zhang H, Gu W, et al. Ginsenoside Rb1 protects hippocampal neurons from high glucose-induced neurotoxicity by inhibiting GSK3β-mediated CHOP induction. Mol Med Rep. 2014 Apr;9(4):1434-8. PMID: 24535619.Ni N, Liu Q, Ren H, et al. Ginsenoside Rb1 protects rat neural progenitor cells against oxidative injury. Molecules. 2014 Mar 7;19(3):3012-24. PMID: 24662068.Xiong Y, Shen L, Liu KJ, et al. Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes. 2010 Oct;59(10):2505-2512. PMID: 20682695.Shen L, Xiong Y, Wang DQ, et al. Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats. J Lipid Res. 2013 May;54(5):1430-1438. PMID: 23434611.Lee JS, Song JH, Sohn NW, Shin JW. Inhibitory effects of ginsenoside Rb1 on neuroinflammation fl=ollowing systemic lipopolysaccharide treatment in mice. Phytother Res. 2013 Sep;27(9):1270-1276. PMID: 23042638.
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メーカー |
品番 |
包装 |
LKT
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G3454
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5 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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