別品名 |
Azalomycin M, Helixin C, Polyetherin A., Antibiotic K 178 Sodium salt
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別包装 |
あり
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純度 |
>=98%
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分子量 |
746.94
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CAS RN® |
28643-80-3
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化合物の概要 |
Polyether cationic ionophore.
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構造 |
C40H67O11Na
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溶媒 |
Soluble in chloroform. Practically insoluble in water.
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使用目的 |
Nigericin is an antibiotic found in Streptomyces that exhibits antibacterial activity against gram positive bacteria. Nigericin inhibits Golgi function and viral activation, acting as an antiviral compound. Nigericin also acts as a H+/K+/Pb2+ ionophore. Additionally, this compound displays pro-inflammatory and immunostimulatory activities, triggering activation of the NALP3 inflammasome.
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その他 |
[融点]245℃-255℃
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参考文献 |
Heid ME, Keyel PA, Kamga C, et al. Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol. 2013 Nov 15;191(10):5230-8. PMID: 24089192.Myskiw C, Piper J, Huzarewich R, et al. Nigericin is a potent inhibitor of the early stage of vaccinia virus replication. Antiviral Res. 2010 Dec;88(3):304-10. PMID: 20951746.
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メーカー |
品番 |
包装 |
LKT
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N3225
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10 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
4℃
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