別品名 |
BRN 1633093
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別包装 |
あり
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純度 |
>=97%
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分子量 |
560.64
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CAS RN® |
30562-34-6
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化合物の概要 |
HSP90 inhibitor.
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構造 |
C29H40N2O9
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溶媒 |
Soluble in DMSO.
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使用目的 |
Geldanamycin is an inhibitor of heat shock protein 90 (HSP90) that exhibits antiviral, neuroprotective, and anticancer activities. Geldanamycin decreases viral titers and inflammation in animal models of Chikungunya virus infection. Geldanamycin also accelerates nerve regeneration and enhances functional recovery in animal models of nerve crush injury. Additionally, geldanamycin sensitizes various cancer cell lines to the effects of other co-administered chemotherapeutics.
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その他 |
[融点]265℃ -268℃
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参考文献 |
Rathore AP, Haystead T, Das PK, et al. Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo. Antiviral Res. 2014 Mar;103:7-16. PMID: 24388965.Sun HH, Saheb-Al-Zamani M, Yan Y, et al. Geldanamycin accelerated peripheral nerve regeneration in comparison to FK-506 in vivo. Neuroscience. 2012 Oct 25;223:114-23. PMID: 22835622.McNamara AV, Barclay M, Watson AJ, et al. Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins. Biochem Pharmacol. 2012 Feb 1;83(3):355-67. PMID: 22138446.
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メーカー |
品番 |
包装 |
LKT
|
G1646
|
1 MG
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※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
-20℃
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