別品名 |
2-Phenyl-1,2-benzisoselenazolin-3-one
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別包装 |
あり
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純度 |
>=98%
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分子量 |
274.18
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CAS RN® |
60940-34-3
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化合物の概要 |
Synthetic glutathione peroxidase mimetic; yeast sporulation inhibitor.
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構造 |
C13H9NOSe
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溶媒 |
Soluble in DMSO.
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使用目的 |
Ebselen is a synthetic glutathione peroxidase mimetic that reacts with cysteine residues; it exhibits antimicrobial, antibacterial, anti-diabetic, and antioxidative activities. Ebselen increases ROS and mitochondrial membrane potential, inhibiting GDH function in vitro. Additionally, ebselen inhibits yeast sporulation and binds the Mycobacterium Ag85 complex, preventing outer membrane synthesis. In diabetic rats, this compound prevents hyperglycemia, decreases glucose levels, Hb1Ac, and oxidative stress, and increases β-cell mass.
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その他 |
[融点]180℃-181℃
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参考文献 |
Azad GK, Singh V, Mandal P, et al. Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target. FEBS Open Bio. 2014 Jan 6;4:77-89. PMID: 24490132.Favrot L, Grzegorzewicz AE, Lajiness DH, et al. Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen. Nat Commun. 2013;4:2748. PMID: 24193546.Mahadevan J, Parazzoli S, Oseid E, et al. Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats. Diabetes. 2013 Oct;62(10):3582-8. PMID: 23801580.
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メーカー |
品番 |
包装 |
LKT
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E0073
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5 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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法規制 |
毒・安・化管
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保存温度 |
-20℃
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