別品名 |
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide, BAY 43-9006
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純度 |
>=98%
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分子量 |
464.82
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CAS RN® |
284461-73-0
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化合物の概要 |
c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.
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構造 |
C21H16ClF3N4O3
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溶媒 |
DMSO 127mg/mL, water:0.01mg/mL
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参考文献 |
Mei J, Zhu X, Wang Z, et al. VEGFR, RET, and RAF/MEK/ERK Pathway Take Part in the Inhibition of Osteosarcoma MG63 Cells with Sorafenib Treatment. Cell Biochem Biophys. 2013 Dec 31. [Epub ahead of print]. PMID: 24375110.Chen ML, Yan BS, Lu WC, et al. Sorafenib relieves cell-intrinsic and cell-extrinsic inhibitions of effector T cells in tumor microenvironment to augment antitumor immunity. Int J Cancer. 2013 Jul 2. [Epub ahead of print]. PMID: 23818246.Wang S, Zhu Y, He H, et al. Sorafenib suppresses growth and survival of hepatoma cells by accelerating degradation of enhancer of zeste homolog 2. Cancer Sci. 2013 Jun;104(6):750-9. PMID: 23421437.Zhang J, Chen YL, Ji G, et al. Sorafenib inhibits epithelial-mesenchymal transition through an epigenetic-based mechanism in human lung epithelial cells. PLoS One. 2013 May 31;8(5):e64954. PMID: 23741434.Carlo-Stella C, Locatelli SL, Giacomini A, et al. Sorafenib inhibits lymphoma xenografts by targeting MAPK/ERK and AKT pathways in tumor and vascular cells. PLoS One. 2013 Apr 19;8(4):e61603. PMID: 23620775.Panka DJ, Wang W, Atkins MB, et al. The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells. Cancer Res. 2006 Feb 1;66(3):1611-9. PMID: 16452220.
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メーカー |
品番 |
包装 |
LKT
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S5868
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100 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
常温
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