別品名 |
[5R-(5α,6β,7α,8α,8aα)]-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione; (+)-Kifunensine; FR 900494
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分子量 |
232.19
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CAS RN® |
109944-15-2
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構造 |
C8H12N2O6
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溶媒 |
DMSO (Slightly, Heated), Methanol (Very Slightly, Heated, Sonicated), Water (Very Slightly, Heated)
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使用目的 |
Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis.When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin.Physicochemical characteristics: Kifunensine is soluble in hot water. Solutions should be made immediately prior to use. The compound should be dessicated and stored at -20 deg C.
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その他 |
[融点]>208℃ (dec.) [性状]White to Off-White Solid [安定性]Desiccate and Store at -20℃
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参考文献 |
Iwami, M., et al.: J. Antibiotic., 40, 612 (1987); Elbein, A.D., et al.: J. Biol. Chem., 265, 15599 (1990); Elbein, A.D., et al.: Archives of Biochem & Biophys., 288, 1, 177 (1991); Kayakiri, H., et al.: Chem. Pharm. Bull., 39(6), 1378 (1991)
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メーカー |
品番 |
包装 |
TRC
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K450000
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10 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
2週間程度
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保存温度 |
-20℃
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