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別品名 [5R-(5α,6β,7α,8α,8aα)]-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione; (+)-Kifunensine; FR 900494
分子量 232.19
CAS RN® 109944-15-2
構造 C8H12N2O6
溶媒 Water (Slightly, Heated)
使用目的 Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis.When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin.Physicochemical characteristics: Kifunensine is soluble in hot water. Solutions should be made immediately prior to use. The compound should be dessicated and stored at -20 deg C.
その他 [融点]>208℃ (dec.)
[性状]White to Off-White Solid
[安定性]Desiccate and Store at -20℃
参考文献 Iwami, M., et al.: J. Antibiotic., 40, 612 (1987); Elbein, A.D., et al.: J. Biol. Chem., 265, 15599 (1990); Elbein, A.D., et al.: Archives of Biochem & Biophys., 288, 1, 177 (1991); Kayakiri, H., et al.: Chem. Pharm. Bull., 39(6), 1378 (1991)


メーカー 品番 包装
TRC K450000 10 MG
希望販売価格 ¥55,000


当社在庫 なし
納期目安 約1.5ヶ月
保存温度 -20℃




メーカー名 Toronto Research Chemicals Inc.
略号 TRC