別包装 |
あり
|
純度 |
>=98%
|
分子量 |
311.34
|
CAS RN® |
85753-43-1
|
化合物の概要 |
Staurosporine analog; PKC and PKA inhibitor.
|
構造 |
C20H13N3O
|
溶媒 |
Soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;Insoluble in water, 2-propanol
|
使用目的 |
K252c is an aglycone analog of staurosporine that acts as a protein kinase inhibitor, inhibiting PKC and potentially PKA. K252c inhibits proliferation of human cytomegalovirus (CMV) and induces apoptosis in cancer cells, indicating some antiviral and anticancer chemotherapeutic activities.
|
その他 |
[外観]White to off white powder
|
参考文献 |
Liu R, Zhu T, Li D, et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2. Arch Pharm Res. 2007 Mar;30(3):270-4. PMID: 17424930.Zimmermann A, Wilts H, Lenhardt M, et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 2000 Oct;48(1):49-60. PMID: 11080540.Fabre S, Prudhomme M, Rapp M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg Med Chem. 1993 Sep;1(3):193-6. PMID: 8081852.
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メーカー |
品番 |
包装 |
LKT
|
K0023
|
0.5 MG
|
※表示価格について
当社在庫 |
なし
|
納期目安 |
1週間程度
|
保存温度 |
4℃
|
|