CpG-B DNA (ODN 2006), Human/Mouse  

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適用 Functional Assay
形状 凍結乾燥品
参考文献 1. Krieg, A; CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002, 20: 709%2. Vollmer, J et al; Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur J Immunol 2004, 34: 251%3. Wang, J et al; CpG-independent synergistic induction of beta-chemokines and a dendritic cell phenotype by orthophosphorothioate ODN and GM-CSF in elutriated human primary monocytes. J Immunol 2005, 174: 6113%4. Heidt, S et al; Intravenous immunoglobulin preparations have no direct effect on B cell proliferation and immunoglobulin production. Clin Exp Immunol 2009, 158:99%5. Capolunghi, F et al; Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients. Rheumatology 2010, 49:2281%6. Saxena, M et al; CpG Protects Human Monocytic Cells against HIV-Vpr?Induced Apoptosis by Cellular Inhibitor of Apoptosis-2 through the Calcium-Activated JNK Pathway in a TLR9-Independent Manner. J Immunol 2011, 187:5865%7. Tadema, H et al; Bacterial DNA motifs trigger ANCA production in ANCA-associated vasculitis in remission. Rheumatology 2011, 50:689%8. Tadema, H et al; Increased Expression of Toll-Like Receptors by Monocytes and Natural Killer Cells in ANCA-Associated Vasculitis, PLoSOne 2011, 6: e24315%9. Rahim, M et al; Ly49Q Positively Regulates Type I IFN Production by Plasmacytoid Dendritic Cells in an Immunoreceptor Tyrosine?Based Inhibitory Motif?Dependent Manner. J Immunol 2013, 190:3994%10. Lepse, N et al; Altered B cell balance, but unaffected B cell capacity to limit monocyte activation in anti-neutrophil cytoplasmic antibody-associated vasculitis in remission. Rheumatology 2014, 53:1683
使用文献 den Hartog G et al., BAFF augments IgA2 and IL‐10 production by TLR7/8 stimulated total peripheral blood B cells, Eur J Immunol. 2018 Feb [DOI]10.1002/eji.201646861
Piano Mortari E et al., The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity., Autophagy. 2018[DOI]10.1080/15548627.2017.1389356
De S et al., B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation., Front Immunol. 2018 Jan[DOI]10.3389/fimmu.2017.01938
Fekete T et al., Regulatory NLRs Control the RLR-Mediated Type I Interferon and Inflammatory Responses in Human Dendritic Cells.,Front Immunol. 2018 Oct[DOI]10.3389/fimmu.2018.02314

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メーカー 品番 包装
HCB HC4039-200NMOL 200 NMOL
希望販売価格 ¥58,000

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メーカー名 Hycult Biotech (Former Hycultbiotechnology)
略号 HCB
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