別品名 |
Wartmannin, KY 12420, SL-2052, (1S,6bR,9aS,11R,11bR)-11-(Acetyloxy)-1,6b,7,8,9a,10,-11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]ideno[4,5-h]-2-benzopyran-3,6,9- trione
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別包装 |
あり
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純度 |
>=97%
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分子量 |
428.43
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CAS RN® |
19545-26-7
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化合物の概要 |
Steroid produced by Penicillum; PI3K, mTOR, DNA-PK, PI4K, MLCK, MAPK, PLK inhibitor.
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構造 |
C23H24O8
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溶媒 |
Soluble in methanol and DMSO.
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使用目的 |
Wortmannin is a steroid metabolite initially produced by fungi in the Penicillum genus. Wortmannin inhibits PI3K, mTOR, DNA-PK, PI4K, MLCK, MAPKs, and polo-like kinases (PLKs). In vivo, wortmannin inhibits activation of Akt and AMPK and decreases translocation of GLUT4, suppressing glucose uptake. Wortmannin also inhibits insulin-induced skeletal myoblast differentiation.
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その他 |
[融点]240℃ [外観]White Powder
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参考文献 |
Zhou X, Zhao Y, Xu L, et al. Wortmannin and U0126 inhibit the promoting effect of insulin on differentiation of skeletal myoblasts in rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jul;30(7):717-20. PMID: 25001936.Ji L, Zhang X, Liu W, et al. AMPK-regulated and Akt-dependent enhancement of glucose uptake is essential in ischemic preconditioning-alleviated reperfusion injury. PLoS One. 2013 Jul 26;8(7):e69910. PMID: 23922853.Zaika O, Lara LS, Gamper N, et al. Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels. J Physiol. 2006 Aug 15;575(Pt 1):49-67. PMID: 16777936.
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メーカー |
品番 |
包装 |
LKT
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W5769
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5 MG
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※表示価格について
当社在庫 |
なし
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納期目安 |
1週間程度
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保存温度 |
-20℃
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